A site on factor XII required for productive interactions with polyphosphate.

Aleksandr Shamanaev,Maxim Litvak,Qiufang Cheng,Michal Ponczek,S Kent Dickeson,Stephanie A Smith,James H Morrissey,David Gailani

Journal of thrombosis and haemostasis : JTH（2023）

引用 3|浏览14

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摘要

FXII Lys, Lys, Lys, and Lys form a binding site for polyanionic substances such as polyphosphate that is required for surface-dependent FXII function.

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关键词

Factor XI,Factor XII,kallikrein-kinin system,polyphosphate,prekallikrein

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