Vasostatin-2 associates with coronary collateral vessel formation in diabetic patients and promotes angiogenesis via angiotensin-converting enzyme 2.

Xiao Lu Bao,Yang Dai, Lin Lu,Xiao Qun Wang,Feng Hua Ding,Wei Feng Shen,Ying Shen,Raffaele De Caterina

European heart journal（2023）

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摘要

Lower serum levels of vasostatin-2 are associated with poor CCV in diabetic CTO patients compared with patients with good CCV. Vasostatin-2 significantly promotes angiogenesis in diabetic mice with hindlimb or myocardial ischemia. Such effects are mediated by ACE2.

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关键词

Angiogenesis,Angiotensin-converting enzyme 2,Coronary collateral vessels,Vasostatin-2

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