Indolocarbazole alkaloid Loonamycin A inhibits triple-negative breast cancer cell stemness and Notch signalling.

Wenwen Xue,Wuhao Li,Ying Yu,Bo Zhang,Yixue Wang,Lin Zhou,Zhixiu Chen,Liwei Wang,Huiming Ge,Qiang Xu,Yan Shen

The Journal of pharmacy and pharmacology（2023）

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摘要

These results reveal a novel bioactivity of indolocarbazole-type alkaloids and provide a promising Notch-inhibiting small molecular candidate for triple-negative breast cancer therapy.

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关键词

Notch signalling,TNBC,cancer stem cell,indolocarbazole alkaloids,loonamycin A

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