Characterization of polypropyleneimine as an alternative transfection reagent

Riku Saeki,Shingo Kobayashi,Rena Shimazui,Teruki Nii,Akihiro Kishimura,Takeshi Mori,Masaru Tanaka,Yoshiki Katayama

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry（2023）

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摘要

Polypropyleneimine (PPI) was examined as a transfection reagent comparing with most widely used polymer, polyethyleneimine (PEI). PPI had better responsiveness to the endosomal pH and showed more condensation ability of plasmid DNA than PEI. Although the cytotoxicity of PPI was somewhat higher than PEI, the transfection efficacy of PPI was comparable with PEI or higher than PEI in some cell line. Thus, PPI would be an alternative transfection reagent. Graphical abstract

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关键词

Polypropyleneimine,Synthetic vector,Transfection

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