BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity.

Xiao-Jun Yu,Ying-Guang Wang,Rui Lu,Xin-Zhen Guo,Yun-Kun Qu,Shan-Xi Wang,Hao-Ran Xu,Hao Kang,Hong-Bo You,Yong Xu

Molecular medicine (Cambridge, Mass.)（2023）

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摘要

Collectively, our findings provided novel mechanistic insights for understanding of the role of BMP7 in IDD of T1DM, and further highlighted BMP7 as a potential therapeutic target for preventing IDD in T1DM.

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关键词

BMP7,Intervertebral disc degeneration,NLRP3 inflammasome activity,Nucleus pulposus cell,Pyroptosis,Type 1 diabetes mellitus

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