Sestrin2 contributes to BRAF inhibitor resistance via reducing redox vulnerability of melanoma cells

Sen Guo,Qiao Yue,Shiyu Wang,Huina Wang,Zhubiao Ye,Weigang Zhang,Qiong Shi,Tianwen Gao,Chunying Li,Guannan Zhu

Journal of dermatological science（2023）

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摘要

•BRAFi resistant melanoma cells experienced significant increased level of Sestrin2, gaining protection from reactive oxidative stress (ROS)- induced cell death under BRAFi exposure.•The activity of mTOR signaling elevated following Sestrin2 ablation.•The combination of mTOR blocker and Sestrin2 knockdown generated enhanced growth suppression effects on BRAFi-resistant melanoma cells.

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关键词

Melanoma,Sestrin2,MTOR,BRAF inhibitor,Resistance

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