TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway.

Tianqi Lu,Ziqi Zhang,Zhenfei Bi,Tianxia Lan,Hao Zeng,Yu Liu,Fei Mo,Jingyun Yang,Siyuan Chen,Xuemei He,Weiqi Hong,Zhe Zhang,Ruyu Pi,Wenyan Ren,Xiaohe Tian,Yuquan Wei,Min Luo,Xiawei Wei

Journal for immunotherapy of cancer（2023）

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摘要

We have revealed that TFAM knockout in DCs ameliorated immune-suppressive microenvironment in tumors through STING pathway. Our work suggests that specific TFAM knockout in DCs might be a compelling strategy for designing novel immunotherapy methods in the future.

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关键词

dendritic cells,antitumor immunity,tfam deficiency,mitochondrial dysfunction,cgas-sting

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