Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer.

Chaofan Liu,Xi Wang,Wan Qin,Jingyao Tu,Chunya Li,Weiheng Zhao,Li Ma,Bo Liu,Hong Qiu,Xianglin Yuan

Cancer communications (London, England)（2023）

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摘要

The combination of ATRi and IR could facilitate anti-PD-L1 therapy by promoting STING signaling in CRC models with different microsatellite statuses. The new combination strategy raised by our study is worth investigating in the management of CRC.

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关键词

ATR inhibitor,DNA damage,PD-L1,SHP1,SUMOylation,cGAS-STING,colorectal cancer,immune checkpoint inhibitor,innate immunity,radiotherapy

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