Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions.
Epilepsia(2023)
摘要
Neither the initial dose, dose escalation, nor the combination with VPA seems to influence the general occurrence of EN. However, EN patients with the recommended starting dose and the recommended dose escalation had the best outcome in terms of clinical severity and mortality.
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关键词
Stevens-Johnson syndrome (SJS),dose escalation,epidermal necrolysis (EN),initial dose,lamotrigine (LTG),toxic epidermal necrolysis (TEN),valproic acid (VPA)
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