Effect of PARP-1 Inhibition on Rotator Cuff Healing: A Feasibility Study Using Veliparib in a Rat Model of Acute Rotator Cuff Repair.

Michael B Künzler,Michelle H McGarry,Masaki Akeda,Hansel Ihn,Agnieszka Karol,Brigitte von Rechenberg,Michael O Schär,Matthias A Zumstein,Thay Q Lee

The American journal of sports medicine（2023）

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摘要

Modulating the inflammatory response through PARP-1 inhibition during the postoperative healing period is a promising approach to improve enthesis healing and reduce rotator cuff retearing. With substances already approved by the Food and Drug Administration, PARP-1 inhibition bears high potential for future translation into clinical application.

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关键词

PARP-1,basic science,enthesis healing,poly-ADP(ribose)polymerase,rotator cuff muscle,rotator cuff tear

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