Effects of Remote Ischemic Preconditioning on Antioxidant Capacity and Lipid Peroxidation in Patients Undergoing Coronary Artery Bypass Grafting in Tehran Heart Center

Background: Remote ischemic preconditioning (RIPC) may improve outcomes in ischemia/reperfusion injury (IRI) by improving antioxidant defense. We investigated total antioxidant capacity (TAC) and malondialdehyde (MDA) content as markers of lipid peroxidation.Methods: The present randomized clinical trial allocated 50 coronary artery bypass graft (CABG) patients with cardiopulmonary bypass at Tehran Heart Center to 2 groups: RIPC and control (25 patients each). Clinical biochemistry parameters, TAC, and MDA were measured at 3 time points: post-anesthesia induction (before skin incision), immediately post-CPB, and 24 hours post-ICU admission.Results: Increased transfusions of packed cells in the ICU and higher plasma MDA levels at post-CPB were observed in the control group. Additionally, significantly higher plasma TAC levels were observed at 24 hours post-ICU in the RIPC group.Conclusions: RIPC protects against IRI in CABG on CPB by reducing lipid peroxidation and elevating antioxidant defense. RIPC could be integrated into CABG to reduce IRI adverse outcomes.