Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Maryam Farzaneh,Ava Nasrolahi,Farhoodeh Ghaedrahmati,Tariq Masoodi,Sajad Najafi,Mohadeseh Sheykhi-Sabzehpoush,Mahrokh Abouali Gale Dari,Klaudia Radoszkiewicz,Shahab Uddin,Shirin Azizidoost,Seyed Esmaeil Khoshnam

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico（2023）

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摘要

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.

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关键词

Cancer,LncRNAs,Pathogenesis,Tumorigenesis,XIST

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