DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury By Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis.

Shuo Huang,Qianyan He,Xin Sun,Yang Qu,Reziya Abuduxukuer,Jiaxin Ren,Kejia Zhang,Yi Yang,Zhen-Ni Guo

Current neurovascular research（2023）

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摘要

Overall, early application of NBP attenuated cerebral ischemia-reperfusion injury by inhibiting mitochondrial Omi/HtrA2-mediated apoptosis in rats. Our study supports a novel neuroprotective mechanism of NBP, making it a promising therapeutic agent for ischemic stroke.

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关键词

DL-3-n-butylphthalide,apoptosis,ischemia-reperfusion injury,mitochondria,neuronal injury

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