Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin-responsive and proopiomelanocortin neurons in the arcuate nucleus.

Wanxin Han,Lei Wang,Kento Ohbayashi,Masakazu Takeuchi,Libbey O'Farrell,Tamer Coskun,Yermek Rakhat,Daisuke Yabe,Yusaku Iwasaki,Yutaka Seino,Toshihiko Yada

Diabetes, obesity & metabolism（2023）

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摘要

GIPFA-085 acutely inhibits feeding and increases lipid utilization, and sustainedly lowers body weight in DIO mice via mechanisms involving rises in leptin and activation of ARC leptin-responsive and POMC neurons. This study highlights the therapeutic potential of GIPRAs for treating obesity and diabetes.

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关键词

GIP receptor agonist,POMC neuron,arcuate nucleus,blood glucose,body weight,food intake,leptin,lipid utilization

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