An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease.

Ye Hua,Wenjing Han, Linfeng Zhou,Jing Gao,Jifeng Zhao,Nanshan Song,Bin Hu,Qingyu Yao, Yumin Liu,Deen Xu,Yunnan Lu,Yi Fan

CNS neuroscience & therapeutics（2023）

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摘要

Our findings confirmed the imbalance of NTN-1/DCC signaling during nigral degeneration in experimental PD models and found for the first time a correlation of plasma NTN-1 with PD symptoms in patients.

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关键词

DCC,Parkinson's disease,netrin-1,neurodegeneration

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