Bilateral Hippocampal Volume Mediated the Relationship Between Plasma BACE1 Concentration and Memory Function in the Early Stage of Alzheimer's Disease: A Cross-Sectional Study.

Wenwen Yin,Ke Wan,Wenhao Zhu,Xia Zhou,Yating Tang,Wenhui Zheng, Jing Cao,Yu Song,Han Zhao,Xiaoqun Zhu,Zhongwu Sun

Journal of Alzheimer's disease : JAD（2023）

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摘要

BACE1 expression increased in the AD continuum, and bilateral hippocampal volume mediated the effect of BACE1 concentration on memory function in patients with MCI. Research has indicated that the plasma BACE1 concentration might be a biomarker at the early stage of AD.

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关键词

Alzheimer’s disease,BACE1,hippocampus,mild cognitive impairment,β-secretase

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