Long Noncoding RNA LINC00578 Inhibits Ferroptosis in Pancreatic Cancer via Regulating SLC7A11 Ubiquitination.

Haoran Li,Yijun Wei,Jie Wang, Jun Yao, Chen Zhang,Chengqing Yu,Yuchen Tang,Dongming Zhu,Jian Yang,Jian Zhou

Oxidative medicine and cellular longevity（2023）

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摘要

This study elucidated that LINC00578 acts as an oncogene to promote pancreatic cancer cell progression and suppress ferroptosis by directly combining with UBE2K to inhibit the ubiquitination of SLC7A11, which provides a promising option for the diagnosis and treatment of pancreatic cancer.

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关键词

rna linc00578 inhibits ferroptosis,slc7a11 ubiquitination,pancreatic cancer

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