Combinatory analysis of immune cell subsets and tumor-specific genetic variants predict clinical response to PD-1 blockade in patients with non-small cell lung cancer.

Nikita Dutta,Anna Rohlin,Ella A Eklund,Maria K Magnusson,Frida Nilsson,Levent M Akyürek,Per Torstensson,Volkan I Sayin,Anna Lundgren,Andreas Hallqvist,Sukanya Raghavan

Frontiers in oncology（2022）

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摘要

Combined analyses of select immune cell subsets and genetic mutations could predict early clinical responses to immunotherapy in patients with NSCLC and after validation, can guide clinical precision medicine efforts.

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关键词

KRAS,PD-1,TP53,effector memory T cells,non-small cell lung cancer

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