Familial CD45RA - T cells to treat severe refractory infections in immunocompromised patients.

Karima Al-Akioui Sanz,Carlos Echecopar Parente,Cristina Ferreras, Marta Menéndez Ribes,Alfonso Navarro,Carmen Mestre,Laura Clares,José Luis Vicario,Antonio Balas,Raquel De Paz,Eduardo López Granados,Elena Sánchez Zapardiel,Carlos Jiménez, María López-Oliva,Esther Ramos,Francisco Hernández-Oliveros,Antonio Pérez-Martínez

Frontiers in medicine（2023）

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摘要

The use of familial CD45RA T-cells containing specific Cytotoxic T-lymphocytes is a feasible, safe and potential effective approach for treating severe pathogen infections in immunocompromised patients through a third party donor. Furthermore, this approach might be of universal use with fewer institutional and regulatory barriers.

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关键词

Aspergillus,BK virus (BKV),CD45RA– T cells,Cytomegalovirus (HCMV),Epstein-Barr virus (EBV),adoptive cell therapy (ACT),mDLI

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