Development of a Next-generation Sequencing-based Gene Panel Test to Detect Measurable Residual Disease in Acute Myeloid Leukemia.

Jin Ju Kim,Ji Eun Jang, Hyeon Ah Lee,Mi Ri Park, Hye Won Kook,Seung-Tae Lee,Jong Rak Choi,Yoo Hong Min,Saeam Shin,June-Won Cheong

Annals of laboratory medicine（2023）

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摘要

Our highly sensitive and accurate NGS-MRD panel can be readily used to monitor most AML patients in clinical practice, including patients without gene rearrangement. In addition, this NGS-MRD panel may allow the detection of newly emerging clones during clinical relapse, leading to more reliable prognoses of AML.

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关键词

Acute myeloid leukemia,High-throughput nucleotide sequencing,Minimal residual disease

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