Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice.

Tingting Li,Lin Yuan,Yijing Zhao,Zige Jiang,Chengcheng Gai,Danqing Xin,Hongfei Ke,Xiaofan Guo,Wenqiang Chen,Dexiang Liu,Zhen Wang, Cyrus S H Ho

Journal of affective disorders（2023）

引用 3|浏览10

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摘要

We demonstrated that targeting OPN expression in microglia/macrophage might help to rescue LPS-induced depressive-like behavior. The underlying mechanism may relate to the modulation of neuroinflammation, BDNF signaling and synaptic structural complexity.

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关键词

Depressive,Microglia,Neuro-inflammation,Osteopontin

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