G q -Mediated Arrhythmogenic Signaling Promotes Atrial Fibrillation.

G-signaling promotes arrhythmogenic atrial Ca-release and AF in mice. Targeting this pathway, ideally using G-selective, biased receptor ligands, may be a promising approach for the treatment and prevention of AF. Importantly, the atrial-specific expression of the G-effector IPR confers atrial selectivity mitigating the risk of life-threatening ventricular pro-arrhythmic effects.