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In advanced-stage non-small cell lung cancer (NSCLC), greater use of tyrosine kinase inhibitor (TKI) therapy has created a uniquely interesting gap in knowledge regarding how to handle patients who respond favorably. In previous generations, when patients with advanced stages of NSCLC experienced favorable responses with more traditional therapies, consolidative or salvage surgery was reserved for the few who passed through a diagnostic, therapeutic, and repeat diagnostic gauntlet. Recent data suggest that among patients with stage IIIB or IV disease treated with TKI, primary tumor resections were associated with increased progression-free and overall survival compared with patients who did not undergo resection. 1 Tseng J.S. Hsu K.H. Zheng Z.R. et al. Primary tumor resection is associated with a better outcome among advanced EGFR-mutant lung adenocarcinoma patients receiving EGFR-TKI treatment. Oncology. 2021; 99: 32-40 Crossref PubMed Scopus (7) Google Scholar The ongoing introduction of newer systemic therapies and their promising outcomes have the potential to expand the pool of patients eligible for the inclusion of surgery as salvage resections. Currently, the decision to pursue salvage surgery is made on an individual case-by-case basis. In an effort to evolve from this paradigm, filling the aforementioned gap in knowledge regarding the effectiveness of salvage surgery, especially following TKI therapy, is of great and timely importance. Salvage Surgery for Advanced Lung Adenocarcinoma After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor TreatmentThe Annals of Thoracic SurgeryVol. 116Issue 1PreviewNo published studies to date have evaluated the detailed pathologic and genetic features of lung adenocarcinoma after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy and salvage surgery. We aimed to evaluate the pathologic and genetic changes of tumors in patients with advanced lung adenocarcinoma treated with EGFR TKI therapy and salvage surgery. Full-Text PDF