Drp1/p53 interaction mediates p53 mitochondrial localization and dysfunction in septic cardiomyopathy.

Riddhita Mukherjee,Laura H Tetri,Sin-Jin Li,Giovanni Fajardo,Nicolai P Ostberg,Kaleb B Tsegay,Kanika Gera,Timothy T Cornell,Daniel Bernstein,Daria Mochly-Rosen,Bereketeab Haileselassie

Journal of molecular and cellular cardiology（2023）

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摘要

Drp1/p53 interaction and mitochondrial localization is a key prodrome to mitochondrial damage in SIMD and inhibiting this interaction may serve as a therapeutic target.

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关键词

Bioenergetics,Isolated cardiomyocyte,LPS sepsis model,Lipopolysaccharide,Mitochondrial dynamics,Mitochondrial fission,Mitochondrial function,Septic cardiomyopathy,deltaPKC

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