External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia.

Shengfeng Wang, Qiufen Yin,Minghua Yang,Zeneng Cheng,Feifan Xie

Pharmaceutics（2023）

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摘要

Some of the published models showed reasonably low levels of bias but had some problems with imprecision, and extensive evaluation is needed before model application in clinical practice.

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关键词

acute lymphoid leukemia,children,external validation,methotrexate,population pharmacokinetics

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