Bruton’s tyrosine kinase inhibition suppresses neutrophilic inflammation and restores histone deacetylase 2 expression in myeloid and structural cells in a mixed granulocytic mouse model of asthma

Ahmed Nadeem,Samiyah Alshehri,Naif O Al-Harbi,Sheikh F Ahmad,Norah A Albekairi,Saleh A Alqarni, Khaild E Ibrahim,Ali S Alfardan,Ali A Alshamrani, Sami B Bin Salman,Sabry M Attia

International Immunopharmacology（2023）

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摘要

•CD11c+ cells, neutrophils and AECs, and lung have decreased HDAC2 and increased p-NFkB levels in mice with mixed granulocytic asthma.•CD11c+ cells, neutrophils and AECs, and lung have increased oxidative inflammation in mice with mixed granulocytic asthma.•Dexamethasone fails to control oxidative inflammation, whereas BTK inhibition controls it.•BTK inhibition restores corticosteroid sensitivity through reduction in pulmonary oxidative stress and restoration of HDAC2.

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关键词

Corticosteroid resistant asthma,Oxidative inflammation,Bruton’s tyrosine kinase,Innate immune cells,HDAC2

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