Clinical outcomes by infusion timing of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.

Adrien Rousseau,Marco Tagliamento,Edouard Auclin,Mihaela Aldea,Maxime Frelaut,Antonin Levy,Jose C Benitez,Charles Naltet,Pernelle Lavaud,Angela Botticella,Miruna Grecea,Nathalie Chaput,Fabrice Barlesi,David Planchard,Benjamin Besse

European journal of cancer (Oxford, England : 1990)（2023）

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摘要

Time-of-day infusion of ICI may impact the survival of patients with advanced NSCLC. Underlying prognostic characteristics and the number of infusions received could represent conceivable confounding factors, linked to increased variance related to ICI infusion timing. Nonetheless, further studies may unravel chronobiological mechanisms modulating ICI efficacy.

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关键词

Anti-PD-1,Anti-PD-L1,Chronomodulation,Chronotherapy,Immune checkpoint inhibitors,Lung cancer,NSCLC,Time-of-day infusion

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