Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Linqiang Ma,Shumin Yang,Yi Yang,Xiangjun Chen,Jun Yang,Yifan He,Qingfeng Cheng,Junlong Li,Bing Kang,Siying Tang,Aipin Zhang,Xiaoyu Shu,Xiaoyu Li,Hang Shen,Ying Jing,Ying Song,Qifu Li,Jinbo Hu

Hypertension (Dallas, Tex. : 1979)（2023）

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摘要

Wolframin is a regulatory protein in aldosterone hypersecretion. Remodeled calcium transportation and mitochondrial function are involved in wolframin-related aldosterone secretion.

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关键词

aldosterone,calcium,hypertension,mitochondria,proteomics

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