Bioequivalence study of ipratropium bromide inhalation aerosol using PBPK modelling.

Jisheng Zhang, Keheng Wu,Bo Liu,Shuguang Hou, Xue Li, Xiang Ye,Jack Liu,Qing He

Frontiers in medicine（2023）

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摘要

This model provided a reliable method for exploring the correlation between and PK studies of IB inhalation aerosols. According to the simulation results, the test and reference products were bioequivalent.

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关键词

B2O simulator,aerodynamic particle size distribution,in vitro and in vivo correlation,ipratropium bromide,physiologically based pharmacokinetic model

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