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The Regioselective Conjugation of the 15-Nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer.

Irina V. V. Varizhuk,Vladimir B. B. Tsvetkov,Ilya Yu. Toropygin,Andrey A. A. Stomakhin,Natalia A. A. Kolganova,Sergei A. A. Surzhikov,Edward N. N. Timofeev

PHARMACEUTICS（2023）

Cited 1|Views28
Key words
therapeutic oligonucleotide,thrombin aptamer,peptide conjugate,anticoagulant,G-quadruplex
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