Synthesis of conjugates of (a R ,7 S )-colchicine with monoterpenoids and investigation of their biological activity

E. S. Shchegravina, S. D. Usova,D. S. Baev,E. S. Mozhaitsev,D. N. Shcherbakov, S. V. Belenkaya, E. A. Volosnikova,V. Yu. Chirkova, E. A. Sharlaeva, E. V. Svirshchevskaya, I. P. Fonareva, A. R. Sitdikova, N. F. Salakhutdinov,O. I. Yarovaya,A. Yu. Fedorov

Russian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia（2023）

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摘要

Conjugates of the natural alkaloid (a R ,7 S )-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

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关键词

SARS-Cov-2 3CLPro,antiproliferative activity,colchicine,molecular docking,monoterpenoids

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