Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19

Ellie Karampini,Helen Fogarty,Stephanie Elliott,Hannah Morrin,Colm Bergin,Jamie M O'Sullivan,Mary Byrne,Ignacio Martin-Loeches,Patrick W Mallon,Gerard F Curley,Siobhan Glavey,Ross I Baker, M Lavin,Roger J S Preston,Cliona Ni Cheallaigh,Soracha E Ward,James S O'Donnell

Research and Practice in Thrombosis and Haemostasis（2023）

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摘要

•Severe COVID-19 is associated with endotheliopathy that plays a key role in immunothrombosis.•Endothelial cell activation correlates with COVID-19 severity and results in Weibel-Palade body exocytosis.•Plasma levels of von Willebrand factor, angiopoietin-2, osteoprotegerin, and soluble thrombomodulin are elevated in patients with severe COVID-19.•Plasma alterations result in endothelial cell activation and Weibel-Palade body secretion and may promote local angiogenesis.

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关键词

angiogenesis,COVID-19,endothelial activation,endothelial cells,Weibel-Palade body

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