Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1.

Nan Yang,Ibrahim Musa,Anish R Maskey,Ke Li,Zhenzhen Wang,Banghao Liang,Shuwei Zhang,Jixun Zhan,Xiu-Min Li

Frontiers in allergy（2022）

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摘要

Formononetin decreased IgE production in human B cell line U266 cells in a dose-dependent fashion through the regulation of XBP-1 ER transcription. Formononetin may be a potential therapy for allergic asthma and other IgE-mediated diseases.

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关键词

IgE heavy chain,IgE inhibition,XBP-1,antiasthma simplified herbal medicine intervention (ASHMI),asthma,formononetin

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