Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca 2+ overload in type 2 diabetes rat hearts.

Arata Osanami,Tatsuya Sato,Yuki Toda,Masaki Shimizu,Atsushi Kuno,Hidemichi Kouzu,Toshiyuki Yano,Wataru Ohwada,Toshifumi Ogawa,Tetsuji Miura,Masaya Tanno

Journal of diabetes investigation（2023）

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摘要

The findings suggest that 90-kDa AMPD3 localized in the endoplasmic reticulum-mitochondria interface promotes formation of the MAM, inducing mitochondrial Ca overload and dysfunction in type 2 diabetes hearts.

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关键词

Adenosine monophosphate deaminase,Diabetic cardiomyopathy,Mitochondria-associated endoplasmic reticulum membrane

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