Murine model of elastase-induced proximal thoracic aortic aneurysm through a midline incision in the anterior neck.

Jianqing Deng,Dandan Li,Xuelin Zhang,Weihang Lu,Dan Rong,Xinhao Wang,Guoyi Sun,Senhao Jia,Hongpeng Zhang,Xin Jia,Wei Guo

Frontiers in cardiovascular medicine（2023）

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摘要

We established a novel mouse model of PTAAs through a midline incision in the anterior neck by peri-adventitial application of elastase. This model may facilitate research into the pathogenesis of PTAA formation and the treatment strategy for this devastating disease.

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关键词

aneurysmal pathology,aortic degenerative disease,elastase,experimental models,thoracic aortic aneurysm

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