Development of a Fast Onset Proton Pump Inhibitor: Comparison of Fixed-Dose Combination of Rabeprazole and Sodium Bicarbonate (YPI-011) to the Conventional Enteric-Coated Rabeprazole.

Sungyeun Bae,Jihoon Kwon,Mi-Hye Lee,Kyung-Sang Yu,SeungHwan Lee

Drug design, development and therapy（2023）

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摘要

The fixed dose combination of rabeprazole with NaHCO showed a faster absorption and consequently, a more rapid gastric acid suppression with a similar systemic exposure of rabeprazole at steady state compared to the conventional enteric-coated rabeprazole.

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关键词

comparative pharmacokinetics/pharmacodynamics,gastroesophageal reflux disease,immediate release,intragastric pH monitoring

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