A new perspective in pyroptosis: lifting the veil on GSDMA activation.

Pyroptosis is an inflammatory form of death mediated by gasdermin that recruits immune cells to the site of infection and promotes protective immunity. The gasdermin is a family of pore-forming proteins, including GSDMA (Gsdma1, Gsdma2, Gsdma3), GSDMB, GSDMC(Gsdmc1, Gsdmc2, Gsdmc3, Gsdmc4), GSDMD (Gsdmd),GSDME/DFNA5 (Dfna5) and GSDMF/DFNB59/PJVK(Dfnb59) [1,2]. Though activation of GSDMB/C/D/E has been gradually illustrated [3], the details of GSDMA activation, particular in epithelial cells such as skin and upper gastrointestinal tract, still remain so far largely elusive.