Parkinson disease primer, part 2: management of motor and nonmotor symptoms

Objective To provide family physicians with an approach to the management of motor and nonmotor symptoms of Parkinson disease (PD). Sources of information Published guidelines on the management of PD were reviewed. Database searches were conducted to retrieve relevant research articles published between 2011 and 2021. Evidence levels ranged from I to III. Main message Family physicians can play an important role in identifying and treating motor and nonmotor symptoms of PD. Family physicians should initiate levodopa treatment for motor symptoms if they affect function and if specialist wait times are long, and they should be aware of basic titration approaches and possible side effects of dopaminergic therapies. Abrupt withdrawal of dopaminergic agents should be avoided. Nonmotor symptoms are common and underrecognized and are a major factor in disability, quality of life, and risk of hospitalization and poor outcomes for patients. Family physicians can manage common autonomic symptoms such as orthostatic hypotension and constipation. Family physicians can treat common neuropsychiatric symptoms such as depression and sleep disorders, and they can help recognize and treat psychosis and PD dementia. Referrals to physiotherapy, occupational therapy, speech language therapy, and exercise groups are recommended to help preserve function. Conclusion Patients with PD present with complex combinations of motor and nonmotor symptoms. Family physicians should have basic knowledge of dopaminergic treatments and their side effects. Family physicians can play important roles in management of motor symptoms and particularly nonmotor symptoms and can have a positive impact on patients' quality of life. An interdisciplinary approach involving specialty clinics and allied health experts is an important part of management.