KLKB1 and CLSTN2 are associated with HDL-mediated cholesterol efflux capacity in a genome-wide association study.

Johanna F Schachtl-Riess,Sebastian Schönherr,Claudia Lamina,Lukas Forer,Stefan Coassin,Gertraud Streiter,Azin Kheirkhah,Yong Li,Heike Meiselbach,Silvia Di Maio,Kai-Uwe Eckardt,Anna Köttgen,Florian Kronenberg

Atherosclerosis（2023）

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摘要

We identified HDL-cholesterol and triglycerides as the main determinants of CEC. Furthermore, we newly found a significant association of CEC with the KLKB1 and the CLSTN2 locus and confirmed the association with the APOE/C1 locus, likely mediated by triglycerides.

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关键词

Cholesterol efflux,GWAS,Genome-wide association study,HDL functionality

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