Mixed meal tolerance testing highlights in diabetes altered branched-chain ketoacid metabolism and pathways associated with all-cause mortality.

Michael Y Mi,Mark Whitlock,Xu Shi,Laurie A Farrell,Victoria M Bhambhani,Juweria Quadir,Matthew Blatnik, Kyle P Wald,Brendan Tierney,Albert Kim, Peter Loudon,Zsu-Zsu Chen,Adolfo Correa,Yan Gao,April P Carson,Alain G Bertoni,Rachel J Roth Flach,Robert E Gerszten

The American journal of clinical nutrition（2023）

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摘要

BCKA levels remained elevated after an MMTT among participants with diabetes, suggesting that BCKA catabolism may be a key dysregulated process in the interaction of BCAA and diabetes. Metabolites with different kinetics after an MMTT may be markers of dysmetabolism and associated with increased mortality in self-identified African Americans.

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关键词

African Americans,Jackson Heart Study,all-cause mortality,branched-chain amino acid,branched-chain ketoacid,diabetes,metabolomics,mixed meal tolerance test

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