Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism.

Nefeli Grammatika Pavlidou,Shokoufeh Dobrev,Kira Beneke,Franziska Reinhardt,Simon Pecha,Eric Jacquet,Issam H Abu-Taha,Constanze Schmidt,Niels Voigt,Markus Kamler,Renate B Schnabel,Istvan Baczkó,Anne Garnier,Hermann Reichenspurner,Viacheslav O Nikolaev,Dobromir Dobrev,Cristina E Molina

European heart journal（2023）

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摘要

Both PDE8A and PDE8B are expressed in human heart. Upregulation of PDE8B isoforms in cAF reduces ICa,L via direct interaction of PDE8B2 with the Cav1.2α1C subunit. Thus, upregulated PDE8B2 might serve as a novel molecular mechanism of the proarrhythmic reduction of ICa,L in cAF.

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关键词

Atrial fibrillation,Calcium handling,ICa,L,PDE8,Phosphodiesterases,cAMP

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