TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma.

Maximilian O Schaettler,Rupen Desai,Anthony Z Wang,Alexandra J Livingstone,Dale K Kobayashi,Andrew T Coxon,Jay A Bowman-Kirigin,Connor J Liu,Mao Li,Diane E Bender,Michael J White,David M Kranz,Tanner M Johanns,Gavin P Dunn

Journal for immunotherapy of cancer（2023）

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摘要

We generated and characterized the first TCR transgenic against an endogenous neoantigen within a preclinical glioma model and demonstrated the therapeutic potential of adoptively transferred neoantigen-specific T cells. The MISTIC mouse provides a powerful novel platform for basic and translational studies of antitumor T-cell responses in glioblastoma.

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关键词

T-lymphocytes,antigens,brain neoplasms,cell engineering,immunotherapy

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