Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.

Weimin Xu,Weijun Ou,Yuan Feng,Qingru Xu,Yili Yang,Long Cui,Peng Du

Journal of gastroenterology and hepatology（2023）

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摘要

GCR may exist in CRC and exert effects on the progression of CRC. Targeted inhibition of UPF3A could reduce the GCR effects and suppress the expression of oncogenic homologue genes corresponding to PTC mutations, indicating a novel therapeutic strategy for treatment of CRC metastasis.

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关键词

Colorectal cancer,Genetic compensation response,Homologue gene,Metastasis,Up-frameshift 3A

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