Association between Severe Acute Respiratory Syndrome Coronavirus 2Infection (Coronavirus Disease 2019) and Lupus Anticoagulant-Hypoprothrombinemia Syndrome: A Case Report and Literature Assessment.

Among the tests that study the presence of circulating antiphospholipid antibodies, the so-called lupus anticoagulant (LA) is considered the main risk factor for venous and arterial thromboembolic disease.[1] However, in some cases, this laboratory test is associated with hemorrhagic diathesis. This primarily occurs when antiprothrombin antibodies with LA activity cause a reduction in plasma prothrombin levels such that hemorrhagic events occur. This clinical situation can be called LA/hypoprothrombinemia syndrome (LAHS).[2] LAHS is considered relatively rare, especially as associated with infection, and specifically SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection.