Activated AMPK-mediated glucose uptake and mitochondrial dysfunction is critically involved in the glutamate-induced oxidative injury in HT22 cell

Shao-Peng Lin,Jingyi Bu,Shan Ye,Qiangda Xie,Jue-Xian Wei,Xiaofang Yin,Fen Mei,Pei-Yi Lin,Xiao-Hui Chen

Tissue and Cell（2023）

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摘要

The hypothetical model proposed by this study. The phosphorylation of AMPK is upregulated during glutamate–induced injury insult, which promotes the glucose metabolism, electron transport chain, oxidative stress and ultimately promotes apoptosis.ga1

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关键词

Glutamate,AMPK,Mitochondria,Reactive oxygen species,Apoptosis

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