Emulating Target Trials to Avoid Immortal Time Bias - An Application to Antibiotic Initiation and Preterm Delivery.

Ellen C Caniglia,Rebecca Zash,Christina Fennell,Modiegi Diseko,Gloria Mayondi,Jonathan Heintz,Mompati Mmalane,Joseph Makhema,Shahin Lockman,Sunni L Mumford,Eleanor J Murray,Sonia Hernández-Díaz,Roger Shapiro

Epidemiology (Cambridge, Mass.)（2023）

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摘要

Defining exposure as antibiotic initiation at any time during follow-up after time zero resulted in substantial immortal time bias, making antibiotics appear protective against preterm delivery. Conducting a sequence of target trials can avoid immortal time bias in pregnancy studies.

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关键词

antibiotic initiation,immortal time bias,target trials

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