Differential Expression of FXR and Genes Involved in Inflammation and lipid Metabolism Indicate Adipose Tissue Dysfunction in Gestational Diabetes.

Jorge Valencia-Ortega,Rebeca González-Reynoso,Mauricio Salcedo-Vargas,Mary Flor Díaz-Velázquez,Edgar Ramos-Martínez,Aldo Ferreira-Hermosillo,Moisés Mercado,Renata Saucedo

Archives of medical research（2023）

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摘要

GDM is associated with decreased expression of FXR and IL-10 and increased expression of LPL, as well as a higher TNF/IL-10 ratio in VAT. These results suggest increased lipid storage and pro-inflammatory state indicating VAT dysfunction in this metabolic disorder.

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关键词

Adipose tissue,Gestational diabetes mellitus,Inflammation,Lipid metabolism,Nuclear receptor

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