Evaluating depressive symptoms, BDNF Val66Met, and APOE-ε4 as moderators of response to computerized cognitive training in heart failure.

Susan J Pressler,Miyeon Jung,Bruno Giordani,Marita G Titler,Irmina Gradus-Pizlo,Kittie Reid Lake,Kelly L Wierenga,David G Clark,Susan M Perkins,Dean G Smith,Evelina Mocci,Susan G Dorsey

Heart & lung : the journal of critical care（2023）

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摘要

Studies are needed to elucidate biological mechanisms of cognitive dysfunction in HF and test novel interventions to improve memory, serum BDNF, working memory, IADLs and HRQL. Patients may need to be stratified or randomized by HF severity within intervention trials.

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关键词

Brain-derived neurotrophic factor,Computerized cognitive training,Congestive heart failure,Health-related quality of life,Heart failure,Memory

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