DZIP1 expressed in fibroblasts and tumor cells may affect immunosuppression and metastatic potential in gastric cancer

Yi Yin,Yuanjie Liu, Yunya Wang,Jiepin Li,Shuo Liang,Wei Zhang, Zhibin Ma,Shenlin Liu,Xi Zou

International Immunopharmacology（2023）

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摘要

•In gastric cancer, DZIP1 was mainly expressed in tumour cells and fibroblasts.•DZIP1 drived gastric cancer progression through EMT and angiogenesis.•DZIP1 was associated with high stromal abundance and T cell dysfunction in TME.

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关键词

Gastric cancer,Tumor microenvironment,DZIP1,Immunotherapy,Fibrosis

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