A Multicenter Allelic Analysis of Diffuse Idiopathic Skeletal Hyperostosis: Nature Versus Nurture?

Thomas M Zervos,Silvienne Sint Jago,Matthew S Erwood,Azam Basheer,Ian Y Lee,Farah D Lubin,Lonni Schultz,Beverly C Walters

Neurosurgery（2023）

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摘要

We identified 5 SNPs in patients with DISH that occurred more frequently than a global reference. We also identified novel environmental associations. We hypothesize that DISH represents a heterogeneous condition with both multiple genetic and environmental influences.

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关键词

Diffuse idiopathic skeletal hyperostosis, DISH, Forestier disease, Ossification of the posterior longitudinal ligament, OPLL, North American, Single nucleotide polymorphism analysis

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